Croscarmellose Sodium (CCNa)

Croscarmellose Sodium (CCNa) powder is a highly cross-linked, carboxymethylated derivative of cellulose. It is widely used in the pharmaceutical, food, and cosmetics industries, primarily as a superdisintegrant in tablet and capsule formulations. Its rapid swelling and excellent water uptake make it ideal for promoting tablet breakup. Healthmove is croscarmellose sodium (CCNa) powder supplier and you can get price here!

Data Sheet

General Information
Product Name	Croscarmellose Sodium（CCNa）
HS Code	39123100
CAS Number	74811-65-7
Standard	CP、USP、EP、BP
Packing Specification	25kg/ drum
Storage Condition	Room temperature, Sealed
Product Character	White or white powder, very wet. Swell in water and form a suspension, insoluble in acetone, anhydrous ethanol, ether, or toluene.

Physicochemical Property
Particle Size	20–200 μm
pH Range	pH 5–7
Density	N/A
Molecular Formula	N/A
Refractive Index	N/A
Boiling Point	N/A
Vapor Pressure	N/A
Molecular Weight	N/A
Fusing Point	＞205℃
Flash Point	N/A

Comparison with Other Disintegrants
Property	Croscarmellose Sodium	Sodium Starch Glycolate (SSG)	Microcrystalline Cellulose (MCC)
Swelling Capacity	High	Moderate	Low
Disintegration Speed	Very Fast	Fast	Moderate
Concentration Used (%)	0.5–5	2–8	10–20
Solubility in Water	Insoluble, swells	Swells	Insoluble, minimal swelling

Features

• Rapid Action: Fast disintegration ensures quick drug release.
• Versatility: Compatible with a wide range of APIs and excipients.
• Low Usage Levels: Effective at concentrations as low as 0.5–5% in formulations.
• pH Stability: Functions well across a broad pH range, making it versatile for various formulations.
• When Croscarmellose Sodiumis used as a disintegrant, the amount can reach 5%, but the amount is usually 2% in the direct tablet process and 3% in the wet pellet press.

Applications

Pharmaceutical Industry

Superdisintegrant:

• Used in oral solid dosage forms like tablets and capsules to ensure rapid disintegration and release of the active ingredient.
• Common in both immediate-release and orally disintegrating tablets (ODTs).

Binder

Croscarmellose Sodium is also present in tablets as a binder, tackifier, and anti-adhesive, as an active ingredient in bulk laxatives, and as a food additive in tablets.

Stabilizer

Croscarmellose Sodium is used as a suspension agent in injectable preparations to promote solubilization of compounds with poor water solubility. Prevents aggregation in suspensions.

Food Industry

Croscarmellose Sodium is a commonly used drug additive approved by the U.S. Food and Drug Administration (FDA). Acts as a stabilizer, thickener, or texturizer in food formulations, especially in gluten-free products.

Cosmetics and Personal Care

Used in formulations like face masks, powders, and gels for its swelling and water-absorption properties.