Hypromellose Acetate Succinate (HPMCAS)

Hypromellose Acetate Succinate (HPMCAS) is a cellulose-derived polymer used extensively in the pharmaceutical industry, primarily as an enteric coating agent and a solubility enhancer for poorly water-soluble drugs. It is particularly valuable in formulating controlled-release systems and enhancing bioavailability through amorphous solid dispersions. Healthmove is Hypromellose Acetate Succinate powder supplier and you can get price here!

Data Sheet

General Information
Product Name	Hypromellose Acetate Succinate（HPMCAS）
HS Code	39129000
CAS Number	71138-97-1
Standard	CP、USP
Packing Specification	15kg/ drum
Storage Condition	Room temperature, Sealed
Product Character	White or yellowish-white powder or particles. It is insoluble in ethanol and water, dissolved in methanol and acetone, and swollen into a clarified or slightly turbidity colloidal solution in cold water.

Grades of HPMCAS

HPMCAS is available in different grades depending on the substitution levels of acetate and succinate. These grades vary in:

• pH Threshold for Dissolution: Dissolution starts at pH 5.0, 5.5, or 6.0, depending on the grade.
• Viscosity: Determines suitability for coating or dispersion.

Common grades include:

• LF: Dissolves at pH ~5.0.
• MF: Dissolves at pH ~5.5.
• HF: Dissolves at pH ~6.0.

Physicochemical Property
Density	N/A
Molecular Formula	C10H20O9
Solubility	Insoluble in water at low pH (acidic conditions). Soluble at higher pH levels (>5.5), ensuring release in the intestines.
pH-Dependent Solubility	Functional as an enteric coating material due to selective solubility.
Thermal Properties	Melting or glass transition temperature varies with substitution levels but typically decomposes above 200°C.
Amphiphilic Nature	Enhances solubility of hydrophobic drugs by forming micelle-like structures.
pKa Value	Around 4.0 due to the succinyl group.
Refractive Index	N/A
Boiling Point	N/A
Vapor Pressure	N/A
Molecular Weight	286.28
Fusing Point	N/A
Flash Point	N/A

Comparison with Other Disintegrants
Property	Croscarmellose Sodium	Sodium Starch Glycolate (SSG)	Microcrystalline Cellulose (MCC)
Swelling Capacity	High	Moderate	Low
Disintegration Speed	Very Fast	Fast	Moderate
Concentration Used (%)	0.5–5	2–8	10–20
Solubility in Water	Insoluble, swells	Swells	Insoluble, minimal swelling

Features

• Selective Solubility: Excellent pH-responsive solubility for enteric applications.
• Enhanced Bioavailability: Improves dissolution rate and absorption of poorly soluble drugs.
• Non-Toxic and Biocompatible: Approved for pharmaceutical use by regulatory authorities like FDA and EMA.
• Versatile Processing: Suitable for spray-drying, hot-melt extrusion, or solvent-based film coatings.

Applications

Pharmaceutical Industry

Enteric Coating

• Protects acid-sensitive drugs, ensuring they reach the intestines for absorption.
• Typical drugs include proton pump inhibitors (e.g., omeprazole).

Solubility Enhancement

• Used in amorphous solid dispersions (ASDs) to improve the solubility and bioavailability of poorly water-soluble drugs.
• Ideal for drugs in Biopharmaceutics Classification System (BCS) Class II and IV.

Controlled Drug Release

• Enables targeted release in the intestines or at specific pH levels.

Matrix Systems

• Forms hydrophilic matrices for sustained-release formulations.

Cosmetics

Hydroxypropyl methylcellulose acetate succinate can be used as an emulsifier to help insoluble substances mix together.

Food and Nutraceuticals

Sometimes used as a coating material or stabilizer for active ingredients in supplements. It can be used as a food additive to increase the consistency and viscosity of food.