Hypromellose Phthalate (HPMCP 55)

Hypromellose Phthalate (HPMCP), also known as Hydroxypropyl Methylcellulose Phthalate, is a cellulose-derived polymer widely used as an enteric coating material in pharmaceutical applications. HPMCP 55 is one of the most common grades, offering excellent pH-dependent solubility and protection for drugs sensitive to stomach acid. Healthmove is a Hypromellose Phthalate Powder supplier and you can get price here!

Data Sheet

General Information
Product Name	Hypromellose Phthalate (HPMCP 55)
HS Code	39129000
CAS Number	9050-31-1
Standard	CP、USP、BP、EP
Packing Specification	25kg/ drum
Storage Condition	Room temperature, Sealed
Product Character	White or white-like powder or particle. It is almost insoluble in water and anhydrous ethanol, slightly soluble in acetone and toluene, and dissolved in methanol-acetone (1:1) and methylene chloride (1:1).

Grades of HPMCP
HPMCP 55	Dissolves at pH 5.5. Suitable for moderately acidic drug delivery.
HPMCP 50	Dissolves at pH 5.0. Suitable for drugs requiring faster intestinal release.
HPMCP 55S	Dissolves at pH 5.8. Used for more delayed drug release.

Physicochemical Property
Density	1.3±0.1g/cm3
Molecular Formula	C14H16N4
Refractive Index	1.681
Boiling Point	456.7±48.0℃ at 760mmHg
Vapor Pressure	0.0±1.1 mmHg at 25℃
Molecular Weight	240.304
Fusing Point	＞145℃
Flash Point	230.0±29.6℃
Film Forming	Produces strong, flexible, and acid-resistant films.
pH-Dependent Solubility	Dissolves at pH ≥ 5.5, ensuring targeted release in the intestines.
Thermal Stability	Decomposes at temperatures above 200°C.

Comparison with Other Enteric Polymers
Property	HPMCP 55	Cellulose Acetate Phthalate (CAP)	Eudragit L100
Solubility Threshold	pH 5.5	pH 5.0	pH 6.0
Film Flexibility	High	Moderate	Moderate
Stability in Storage	Excellent	Moderate	Excellent
Environmental Concerns	Organic solvents required	Organic solvents required	Aqueous systems available

Features

• Selective Dissolution: Excellent enteric protection with precise pH-triggered solubility.
• Biocompatibility: Safe and widely approved for pharmaceutical applications.
• Film Quality: Strong, durable, and flexible films resistant to cracking.
• Versatility: Compatible with organic solvents and aqueous dispersion methods.

Applications

Pharmaceutical Industry

Enteric Coating:

• Protects acid-sensitive drugs from gastric degradation.
• Prevents gastric irritation caused by certain active ingredients.
• Ensures drug release in the intestines.

Modified-Release Systems:

• Enables targeted release in the duodenum or jejunum.

Capsule Coating

• Used as a film-forming agent for enteric gelatin or HPMC capsules.

Food and Nutraceuticals

• Sometimes applied in dietary supplements to protect sensitive ingredients or delay release.