Low-Substituted Hydroxypropyl Cellulose (L-HPC)

Low-Substituted Hydroxypropyl Cellulose (L-HPC) is a partially etherified cellulose derivative with a low degree of substitution by hydroxypropyl groups. It is widely used in pharmaceutical formulations, primarily as a disintegrant and binder in solid dosage forms such as tablets and capsules. Its unique properties stem from its balance of water-insoluble cellulose and hydrophilic hydroxypropyl groups. Healthmove is a Low-Substituted Hydroxypropyl Cellulose Powder and you can get the price here.

Data Sheet

General Information
Product Name	Low-Substituted Hydroxypropyl Cellulose (L-HPC)
HS Code	39129000
CAS Number	9004-64-2
Standard	CP、USP、BP、EP
Packing Specification	20kg/ drum、20kg/ bag
Storage Condition	Room temperature, Sealed
Product Character	White or white powder. Insoluble in ethanol, acetone, or ether.

Grades of L-HPC
Fine Grades	For direct compression or formulations requiring rapid disintegration.
Coarse Grades	Suitable for wet granulation and formulations requiring mechanical strength.
Customized Grades	Tailored for specific disintegration times and tablet hardness requirements.

hysicochemical Property
Density	1.3±0.1g/cm3
Molecular Formula	C36H70O19
Refractive Index	1.532
Boiling Point	891.2±65.0℃ at760mmHg
Vapor Pressure	0.0±0.6mmHg at 25℃
Molecular Weight	806.93
Fusing Point	N/A
Flash Point	492.8±34.3℃
Particle Size	Available in fine powder and granule grades, which can be customized for specific applications.
Moisture Content	L-HPC is hygroscopic and retains a small amount of moisture.
pH Stability	Stable in the pH range of 3.0 to 9.0.

Comparison with Other Disintegrants
Property	L-HPC	Sodium Starch Glycolate	Crospovidone
Solubility	Insoluble (swells in water)	Insoluble (swells in water)	Insoluble
Disintegration Speed	Moderate to High	High	Very High
Compatibility	Non-ionic, broad compatibility	Limited to neutral drugs	Broad compatibility
Compression Properties	Provides binding	Minimal binding	Minimal binding

Features

• Rapid Swelling: Swells efficiently in aqueous environments to enhance tablet disintegration.
• Non-Ionic Nature: Compatible with a wide range of drugs and excipients.
• Insolubility: Maintains structural integrity in water, making it ideal for controlled-release systems.
• High Stability: Chemically stable over a broad range of pH and environmental conditions.
• Versatility: Usable in direct compression, wet granulation, and dry granulation processes.

Applications

Pharmaceutical Industry

• Tablet Disintegrant: Ensures rapid disintegration in aqueous media by swelling and promoting particle dispersion.
• Binder: Serves as a binder in wet and dry granulation processes.
• Controlled-Release Systems: Used in certain matrix formulations for modified drug release.
• Capsule Filler: Acts as a diluent and disintegrant in capsule formulations.

Food and Nutraceuticals

Occasionally used as a dietary fiber or texturizing agent in supplements.

Cosmetics and Personal Care

Functions as a stabilizer or suspending agent in creams and lotions, though this use is less common.