Microcrystalline Cellulose (MCC)

Microcrystalline Cellulose (MCC) is a refined, partially depolymerized cellulose derived from natural sources such as wood pulp or cotton. It is widely used as an excipient in pharmaceutical, food, and cosmetic formulations due to its excellent compressibility, binding properties, and inert nature. Healthmove is a Microcrystalline Cellulose Powder supplier and you can get the price here.

Data Sheet

General Information
Product Name	Microcrystalline Cellulose (MCC)
HS Code	39129000
CAS Number	9004-34-6
Standard	CP、USP、BP、EP
Packing Specification	20kg/ drum、20kg/ bag
Storage Condition	Room temperature, Sealed
Product Character	White or white powder or granular powder. It is almost insoluble in water, ethanol, ether, dilute sulfuric acid or 5% sodium hydroxide solution.

Grades of L-HPC
PH-101	Standard grade for general pharmaceutical applications.
PH-102	Slightly larger particle size, offering better flow properties.
PH-200	Higher bulk density and larger particle size, suitable for high-dose formulations.
PH-301/PH-302	Lower moisture content for moisture-sensitive formulations.

Physicochemical Property
Density	1.3±0.1g/cm3
Molecular Formula	C36H70O19
Refractive Index	1.532
Boiling Point	891.2±65.0℃ at760mmHg
Vapor Pressure	0.0±0.6mmHg at 25℃
Molecular Weight	806.93
Fusing Point	N/A
Flash Point	492.8±34.3℃
Particle Size	Varies depending on grade (fine powders to granules).
Moisture Content	Hygroscopic, typically ≤ 5% w/w.
pH Stability	Stable over a wide pH range (3–7.5).

Comparison with Other Excipients
Property	MCC	Lactose	Starch
Solubility	Insoluble, swells in water	Soluble in water	Swells, partially soluble
Compressibility	Excellent	Moderate	Poor
Disintegration Speed	Moderate	Slow	High
Flowability	Good	Moderate	Poor

Features

• Inert and Biocompatible: Safe and non-reactive with active ingredients.
• Versatility: Suitable for both direct compression and wet granulation methods.
• Improved Flow Properties: Facilitates efficient powder handling during manufacturing.
• Enhanced Stability: Chemically stable over a wide range of conditions.
• Sustainable: Derived from renewable cellulose sources.

Applications

Pharmaceutical Industry

Tablet and Capsule Excipient

• Serves as a binder, diluent, and disintegrant.
• Compatible with direct compression and wet granulation methods.

Controlled Release Systems

• Acts as a matrix-forming agent in sustained-release formulations.

Co-processed Excipients:

• MCC is often combined with other materials like lactose to improve functionality.

Topical and Liquid Dosages

• Used as a suspending agent or thickener.

Food Industry

• Used as a stabilizer, thickener, anti-caking agent, and texturizer in processed foods and supplements.

Cosmetic Industry

• Functions as a thickening agent and stabilizer in creams, lotions, and other personal care products.