Silicified Microcrystalline Cellulose (SMCC)

Silicified Microcrystalline Cellulose (SMCC)

Silicified Microcrystalline Cellulose (SMCC) is a co-processed excipient combining microcrystalline cellulose (MCC) with colloidal silicon dioxide (CSD). This hybrid material enhances the functionality of MCC by improving its flow properties, compressibility, and stability, making it ideal for direct compression and other solid dosage forms. Healthmove is a Silicified Microcrystalline Cellulose powder supplier and you can get the price here.

Data Sheet

General Information

Product Name Silicified Microcrystalline Cellulose
HS Code 39129000
CAS Number 9004-34-6
Standard CP、USP
Packing Specification 20kg/ drum、20kg/ bag
Storage Condition Room temperature, Sealed
Product Character This product is white or white fine particles or powder. This product is insoluble in water, dilute acid, 5% sodium hydroxide solution, acetone, ethanol or toluene.

Grades of SMCC

ProSolv SMCC 50 Fine particle size for small tablets or high-precision applications.
ProSolv SMCC 90 Medium particle size for general-purpose use.
ProSolv SMCC HD High-density grade for applications requiring compact formulations.

Physicochemical Property

Density 0.3–0.5 g/cm³ (depending on grade).
Particle Size Varies depending on grade; typically between 20–200 microns.
Specific Surface Area Enhanced due to the addition of colloidal silicon dioxide.
Moisture Content Low moisture, typically ≤ 5% w/w.
Molecular Formula N/A
Refractive Index N/A
Boiling Point N/A
Vapor Pressure N/A
Molecular Weight N/A
Fusing Point N/A
Flash Point N/A

Comparison with Microcrystalline Cellulose (MCC)

Property MCC SMCC
Flowability Moderate Excellent
Compressibility Excellent Superior
Moisture Resistance Moderate High
Suitability for DC Good Excellent
Cost Lower Higher

Features

  • Improved Flow: Silicon dioxide eliminates bridging and enhances flowability for efficient tablet manufacturing.
  • Enhanced Compactibility: Produces tablets with superior hardness and reduced friability.
  • Versatile Use: Suitable for direct compression, dry granulation, and wet granulation.
  • Moisture Resistance: Protects moisture-sensitive active ingredients, extending shelf life.
  • Reduced Dusting: Easier handling compared to pure MCC.

Applications

Pharmaceutical Industry

  • Direct Compression: Suitable for high-speed tableting processes due to enhanced flow and compressibility.
  • Binder and Filler: Used in tablets and capsules to improve cohesion and bulk.
  • Controlled Release Formulations: Can be incorporated into hydrophilic matrices for sustained-release systems.
  • Moisture-Sensitive Formulations: The silicon dioxide component provides added protection against humidity.

Nutraceuticals

  • Commonly used in dietary supplements for tablet and capsule formulations.

Food and Cosmetics

  • Acts as a stabilizer, anti-caking agent, and bulking agent in powdered products.
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Customized Services Available

We not only supply existing conventional standard materials, but also work with many cooperative laboratories and co-built laboratories to provide ODM services. These laboratories focus on inspection work and actively develop new demand products, aiming to effectively adapt to the diversified needs of the market and provide customers with more comprehensive and forward-looking services and product support.

  • ODM Services
  • OEM Services

10+ Years Supplying Chain Experience

Our team has accumulated more than ten years of professional experience in material supply. The company has a number of cooperative and co-built factories to ensure product quality and stable supply. We can offer personalized supply chain solutions based on your specific needs, while achieving rapid delivery of purchased materials, effectively reducing your procurement costs and helping you improve your efficiency.

  • Pharmaceutical Excipients
  • General Chemicals
  • Active Pharmaceutical Ingredients
  • Pharmaceutical Intermediates
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