Magnesium Stearate (MS)

Magnesium Stearate (MS)

This product is a combination of magnesium and stearic acid. It is a mixture of magnesium stearate (C36H70MgO4) and magnesium palmitate (C32H62MgO4) as the main components. According to the dry product calculation, the magnesium content should be 4.0%~5.0%. This product is mainly used as a lubricant or anti-stick agent for tablets and capsules, the general concentration is 0.25-2.0%, due to its hydrophobicity, it can delay the dissolution rate of solid preparations of drugs, so it is required to use the concentration as low as possible, and should avoid the use of drugs with alkaline incompatibility.

Data Sheet

General Information
Product Name Magnesium Stearate(MS)
HS Code 3824999999
CAS Number 557-04-0
Standard CP、USP、EP、BP
Packing Specification 10kg/ bag、15kg/ bag
Storage Condition Room temperature, Sealed
Product Character This product is white easy sand free fine powder, slightly special odor; It is greasy in contact with the skin, insoluble in water, ethanol and ether, slightly soluble in hot benzene and 95% ethanol.
Physicochemical Property
Density N/A
Molecular Formula C22H39NaO4
Refractive Index N/A
Boiling Point 483.4℃ at 760mmHg
Vapor Pressure N/A
Molecular Weight 390.53
Fusing Point N/A
Flash Point 153.5℃

Features

  •   Magnesium stearate is hydrophobic and can block the dissolution of the drug from the solid preparation. Use as little as possible in your prescription.
  •   The retarding effect of magnesium stearate leads to a decrease in dissolution rate, which can be eliminated by adding a high expansion disintegrant to the prescription.
  •   The physical properties of magnesium stearate will vary with the manufacturer and different batch numbers, and the various physical properties of different batches of magnesium stearate, such as specific surface area, particle size, crystal structure, water content and fatty acid composition, are related to the lubrication effect.
  •   Compatibility with strong acids, bases, and iron salts is contraindicated to avoid mixing with strong oxides, and magnesium stearate should not be used in products containing aspirin, some vitamins, and most alkaloid salts.
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